AI Article Synopsis
- The report details the total synthesis of landomycins Q and R, along with the core component anhydrolandomycinone and its analogue.
- It highlights an innovative acetate-assisted arylation method for creating the complex B-ring and a one-pot procedure that simplifies overall synthesis steps.
- Cytotoxicity and antibacterial studies indicate that landomycin R shows promise as an antibacterial agent, particularly against methicillin-resistant strains.
Article Abstract
Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the core component and a one-pot aromatization-deiodination-denbenzylation procedure to streamline the global functional and protecting group manuipulation. Subsequent cytotoxicity and antibacterial studies revealed that the landomycin R is a potential antibacterial agent against methicillin-resistant .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695357 | PMC |
| http://dx.doi.org/10.1039/d1ra01088c | DOI Listing |
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