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| http://dx.doi.org/10.3389/fpsyg.2022.875740 | DOI Listing |
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Promoting Physical Activity in People With Parkinson's Disease Through a Smartphone App: A Pilot Study.
J Neurol Phys Ther
January 2025
Center of Expertise for Parkinson & Movement Disorders, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Gelderland, the Netherlands (S.S., N.M.V., S.K.L.D., B.R.B.); Harvard Medical School, Boston, Massachusetts (A.A., M.A.S., E.A.M.); Departments of Epidemiology and Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts (A.A.); Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts (M.A.S., E.A.M.); Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts (M.A.S.); and Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts (E.A.M.).
Background And Purpose: Physical activity has beneficial symptomatic effects for people with Parkinson's disease (PD), but increasing-and sustaining-a physically active lifestyle remains challenging. We investigated the feasibility (ability to increase step counts) and usability of a behavioral intervention using a motivational smartphone application to remotely increase physical activity in PD.
Methods: We performed a 4-week, double-blind pilot trial.
Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury.
Front Immunol
January 2025
Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Cells die by necrosis due to excessive chemical or thermal stress, leading to plasma membrane rupture, release of intracellular components and severe inflammation. The clearance of necrotic cell debris is crucial for tissue recovery and injury resolution, however, the underlying mechanisms are still poorly understood, especially . This study examined the role of complement proteins in promoting clearance of necrotic cell debris by leukocytes and their influence on liver regeneration.
View Article and Find Full Text PDFChampioning fundamental discovery research: quality over quantity.
FEBS J
January 2025
Department of Structural Biology, University of Pittsburgh School of Medicine, PA, USA.
Rapidly emerging technologies, such as generative AI tools, have already had a reverberating impact on science and society. The notion that such tools could be entrusted with 'mapping' the trajectory of scientific discovery toward immediate measurable applications, however, is problematic. I instead argue that curiosity-driven fundamental research should remain the base upon which to build progress.
View Article and Find Full Text PDFCausal contextual bandits with one-shot data integration.
Front Artif Intell
December 2024
Robert Bosch Center for Data Science and Artificial Intelligence, Indian Institute of Technology Madras, Chennai, India.
We study a contextual bandit setting where the agent has access to causal side information, in addition to the ability to perform multiple targeted experiments corresponding to potentially different context-action pairs-simultaneously in one-shot within a budget. This new formalism provides a natural model for several real-world scenarios where parallel targeted experiments can be conducted and where some domain knowledge of causal relationships is available. We propose a new algorithm that utilizes a novel entropy-like measure that we introduce.
View Article and Find Full Text PDFNorm strength and norm stability.
Curr Opin Psychol
November 2024
University of Pennsylvania, Philadelphia, PA United States. Electronic address:
In our review, we explore two different flavors of social norms: strength and stability. These two fundamental features are crucial for understanding norm change and designing effective interventions. Strong norms, which significantly influence behavior and are widely adopted, and stable norms, which endure over time, are essential for group coordination and addressing collective challenges.
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