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Neoadjuvant or perioperative immunotherapy for resectable melanoma: The need for biomarkers.
Eur J Cancer
January 2025
National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark. Electronic address:
Groundbreaking studies have reshaped the treatment landscape for patients with resectable stage ≥IIIB melanoma by demonstrating the benefits of neoadjuvant therapy. Data from the NADINA and SWOG S1801 trials reveal substantial improvements in event-free survival compared to adjuvant therapy alone. These studies employed distinct neoadjuvant immunotherapy approaches - ipilimumab plus nivolumab in NADINA and anti-PD-1 monotherapy in SWOG S1801 - highlighting potential differences in efficacy and toxicity.
View Article and Find Full Text PDFEmbracing the mental health challenges of uterus transplant candidates.
Acta Obstet Gynecol Scand
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Division of Transplantation, Department of Surgery, University of Alabama, Birmingham, Alabama, USA.
Uterus transplantation (UTx) has emerged from clinical trials and is expected to become the standard of care for uterine factor infertility. Uterus transplant candidates historically have had to meet strict eligibility criteria to participate in clinical trials. Continued application of psychologic selection criteria from clinical trial may hinder the expansion of UTx.
View Article and Find Full Text PDFTransforming hyperthermic intraperitoneal chemotherapy: using computer simulation to improve HIPEC treatments.
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Department of Anesthesiology, Pain Management & Perioperative Medicine, Henry Ford Health, Detroit, MI, USA.
Pain and Inflammation After Joint Replacement Are Variable Among Patients, Depending on the Individual Biological Factors: Commentary on an article by Julian Wier, MD, et al.: "Complete Blood Cell Count-Based Ratios Identify Total Joint Arthroplasty Patients Likely to Benefit from Perioperative Dexamethasone".
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Zucker School of Medicine, Hofstra/Northwell, Hofstra University, Hempstead, New York.
Integrating Chronic Disease Management and Harm Reduction for Youth with Juvenile Idiopathic Arthritis Amid Canada's Overdose Crisis.
Children (Basel)
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Section of Rheumatology, Department of Paediatrics, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, 28 Oki Drive NW, Calgary, AB T3B 6A8, Canada.
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition in children that often requires long-term pain management, which can include opioid use. In the context of Canada's ongoing overdose crisis, youth with JIA face risks due to potential opioid dependency and exposure to toxic drug supplies. This commentary proposes an integrated approach combining chronic disease management with harm reduction strategies specifically tailored for JIA patients.
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