AI Article Synopsis
- Ligand recognition by cell-surface receptors is essential for both immunity and development in plants and animals, but how this signaling is regulated remains unclear.* -
- This study reveals that plant receptors for pathogens and developmental peptides share a common regulatory module involving type-2C protein phosphatases that dampen signaling in the absence of ligands.* -
- Upon ligand binding, these receptors activate unique kinases that subsequently phosphorylate phosphatases, enhancing receptor signaling and highlighting a shared regulatory circuit for immune and developmental processes in plants.*
Article Abstract
Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signalling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signalling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development uses a similar regulatory module. In the absence of ligand, signalling is dampened through association with specific type-2C protein phosphatases. Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting receptor signalling. Our work reveals a regulatory circuit shared between immune and developmental receptor signalling, which may have broader important implications for plant receptor kinase-mediated signalling in general.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639402 | PMC |
| http://dx.doi.org/10.1038/s41477-022-01134-w | DOI Listing |
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