AI Article Synopsis
- The study investigates the role of the microbiome in uveitic glaucoma (UG) by comparing the eyelid and buccal microbiomes of UG patients to control subjects.
- Researchers collected specimens from 34 UG patients and 25 controls, using 16S ribosomal DNA sequencing to assess microbial diversity and differences.
- Findings indicated lower alpha-diversity and higher beta-diversity in UG patients' microbiomes, with specific taxa differences such as higher levels of Paenibacillus and Faecalibacterium, and lower levels of Lactococcus.
Article Abstract
Background: The microbiome could trigger inflammation leading to epigenetic changes and is involved in the pathophysiology of eye diseases; however, its effect on uveitic glaucoma (UG) has not been fully investigated. This study analysed the differences in eyelid and buccal microbiomes in patients with UG using next-generation sequencing.
Methods: The eyelid and buccal specimens of 34 UG and 25 control patients were collected. The taxonomic composition of the microbiome was obtained via 16S ribosomal DNA sequencing. Diversity and differential gene expression analyses (DEG) determined taxon differences between the microbiomes of UG and control groups.
Results: In both the eyelid and buccal microbiomes, alpha-diversity was lower in UG patients than controls, while beta-diversity in patients with UG was higher than in controls. DEG analysis of the eyelid microbiome revealed various taxa differences, including enrichment of Paenibacillus and Dermacoccus (p-value, 1.31e and 1.55e, respectively) and depletion of Morganella and Lactococcus (p-value, 6.26e and 2.55e, respectively) in patients with UG. In the buccal microbiome, taxa such as Lactococcus was significantly depleted (p-value, 1.31e), whereas Faecalibacterium was enriched in patients with UG (p-value, 6.12e).
Conclusions: The eyelid and buccal microbiomes in patients with UG differ from controls, which raises concerns surrounding environmental influences on the pathogenesis of UG. The reduced Lactococcus in the eyelid and buccal area suggest that microbiota dysbiosis is associated with UG.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012020 | PMC |
| http://dx.doi.org/10.1186/s12886-022-02395-x | DOI Listing |
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