AI Article Synopsis
- - Research focused on creating new compounds based on the antibiotic natural product hunanamycin A, followed by testing their biological effectiveness.
- - A promising compound, identified as compound 36, showed strong activity against Salmonella enterica and had favorable drug-like properties.
- - Testing in Swiss albino mice indicated that compound 36 was not acutely toxic at doses up to 2 g/kg, suggesting its potential for treating foodborne infections caused by Salmonella.
Article Abstract
Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.
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| http://dx.doi.org/10.1016/j.ejmech.2022.114245 | DOI Listing |
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