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Organ-Specific Responses to Chronic High-Fat Diets in Mice: Insights into Phospholipid Fatty Acid Distribution.
Nutrients
February 2025
Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
: This research aimed to investigate phospholipid fatty acid (PLFA) distribution in the brain, kidneys, and white adipose tissue (WAT) and lipid profiles in response to high-fat diets. : Adult female C57BL/6 mice were fed high-fat diets containing 25% linseed, palm, or sunflower oil for 100 days. The fatty acid composition of dietary oils and tissue PL were analyzed using gas-liquid chromatography.
View Article and Find Full Text PDFAn Acid-Base Proton Transfer Approach to Robust Superhydrophobic Self-Cleaning Surfaces for the Corrosion Protection of Magnesium.
Materials (Basel)
February 2025
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China.
In this study, an acid-base proton transfer method was used to fabricate functional coatings on Mg surfaces with the cooperative effect of durable superhydrophobic and exceptional self-cleaning properties, providing high-efficiency corrosion protection. In this context, aluminum chloride served as a precursor for the direct growth of aluminum hydroxide on the Mg surface. Without the addition of any solvent, the densely arranged absolute palmitic acid was strongly bonded to the grown aluminum hydroxide on the Mg substrate, which acted as an effective anti-water barrier that can impede the penetration of water, as well as the oxygen and chloridion involved.
View Article and Find Full Text PDFPolyethylene Glycol Loxenatide Accelerates Diabetic Wound Healing by Downregulating Systemic Inflammation and Improving Endothelial Progenitor Cell Functions.
Int J Mol Sci
March 2025
Key Laboratory of Endocrinology National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Diabetes wound healing presents several significant challenges, which can complicate recovery and lead to severe consequences. Polyethylene glycol loxenatide (PEG-loxe), a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA), shows cardiovascular benefits, yet its role in diabetic wound healing remains unclear. Diabetic mice received PEG-loxe (0.
View Article and Find Full Text PDFUnveiling the Mechanism of Action of Palmitic Acid, a Human Topoisomerase 1B Inhibitor from the Antarctic Sponge .
Int J Mol Sci
February 2025
Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Cancer remains a leading cause of death worldwide, highlighting the urgent need for novel and more effective treatments. Natural products, with their structural diversity, represent a valuable source for the discovery of anticancer compounds. In this study, we screened 750 Antarctic extracts to identify potential inhibitors of human topoisomerase 1 (hTOP1), a key enzyme in DNA replication and repair, and a target of cancer therapies.
View Article and Find Full Text PDFA Study of the Catalytic System HPWO/Quaternary Phosphonium Salts for the Epoxidation of Fatty Acid Methyl Esters-The Effect of the Molar Ratio of Hydrogen Peroxide to the Double Bond.
Molecules
February 2025
Department of Organic Chemical Technology and Polymer Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Pułaskiego 10, 70-322 Szczecin, Poland.
In the present work, the epoxidation of fatty acid methyl esters (biodiesel or FAMEs) with an iodine number of 96.4 g/100 g and containing approximately 11% palmitic acid, 4% stearic acid, 51% oleic acid, 25% linoleic acid, and 5% linolenic acid was studied with an aqueous HO solution and different quaternary phosphonium salts (QPSs) combined with the phosphotungstic heteropolyacid (HPA) HPWO in a biphasic system. The effect of the molar ratio of HO:C=C on the epoxidation of FAMEs was investigated.
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