AI Article Synopsis
- Neutrophils play a crucial role in the immune response against fungal infections, specifically against Candida albicans.
- They require significant amounts of glucose to perform their effective functions during the immune response.
- The study by Li et al. reveals that neutrophils adjust the production and placement of Glucose Transporter 1 (GLUT1) to enhance glucose uptake for their metabolic needs when fighting fungal infections.
Article Abstract
Neutrophils enforce frontline immunity to fungal infection. Potent neutrophil effector functions require vast amounts of cytosolic glucose. Li et al. describe how neutrophils, upon interaction with Candida albicans, modulate the new synthesis and membrane localization of Glucose Transporter 1 (GLUT1) to facilitate glucose entry and meet neutrophils' metabolic needs.
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| http://dx.doi.org/10.1016/j.chom.2022.03.027 | DOI Listing |
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