Twelve new tanzawaic acid derivatives, penitanzacids A-F (), and G-J (), and hatsusamides C-D (), together with two revised structures [tanzawaic acids I-J ()] and three known compounds () were isolated from the deep-sea-derived fungus sp. KWF32. Their structures including absolute configurations were elucidated by spectroscopic data analysis, HRESIMS data, modified Mosher's method, chemical degradation studies, ECD calculations, single crystal X-ray diffraction, and biogenic considerations in comparison with reported known analogues. Penitanzacids H-J () represent the first examples of this family with a side chain and support the proposed biosynthetic pathway in which the side chain is connected to the decalin backbone. Hatsusamides C-D () have a hybrid skeleton formed by linking a tanzawaic acid and a diketopiperazine through an ester bond. Compounds and exhibit weak cytotoxicity against the A549 cell line.
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