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Successful treatment of severe acrodermatitis continua of hallopeau with Bimekizumab: A case report.

SAGE Open Med Case Rep

January 2025

Faculty of Medicine, Division of Dermatology, University of Ottawa, Ottawa, ON, Canada.

Acrodermatitis continua of Hallopeau is a rare form of pustular psoriasis affecting the acral fingers and toes, characterized by recurrent eruptions of sterile pustules that lead to significant pain and potentially irreversible destruction of the nail apparatus. Symptoms are often refractory to topical and systemic therapies for psoriasis. This case report presents a healthy 23-year-old female with severe acrodermatitis continua of Hallopeau, destructing all 10 fingernails.

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Objectives: Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency.

Case Presentation: This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention.

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Zinc Supplementation for Acrodermatitis Enteropathica Overlapped with Psoriasiform Lesions.

Psoriasis (Auckl)

November 2024

Department of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai, 200052, People's Republic of China.

Acrodermatitis enteropathica (AE) can be caused by inherited or acquired zinc deficiency, among which site-specific skin lesions or even psoriasiform skin manifestations are present. Few cases exist in the literature involving the diagnosis and treatment of AE overlapped with psoriasiform lesions. In this case, we reported a teenage boy presented characteristic site-specific skin lesions of AE with low serum zinc level, subsequently progressed into generalized pustular psoriasiform manifestations under a genetic background, while a rapid recovery was observed after monotherapy of zinc supplementation.

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Article Synopsis
  • A two-year-old girl experienced misdiagnoses such as tinea corporis and psoriasis, leading to ineffective treatments until a proper evaluation revealed her low zinc levels.
  • After being diagnosed with AE, she was treated with zinc sulfate, resulting in the complete resolution of her skin lesions within two weeks.
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