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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction.
Front Physiol
January 2025
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
Introduction: Interleukin-10 (IL-10) is a potent immunomodulatory cytokine widely explored as a therapeutic agent for diseases, including myocardial infarction (MI). High-dose IL-10 treatment may not achieve expected outcomes, raising the question of whether IL-10 has dose-dependency, or even uncharted side-effects from overdosing. We hypothesized that IL-10 has dose-dependent effects on macrophage (Mφ) phenotypic transition and cardiac remodeling after MI.
View Article and Find Full Text PDFPromoting longus colli muscle activation: Force direction in sitting matters.
Musculoskelet Sci Pract
January 2025
Ascension Resurrection Family Medicine Residency Program, 7447 W Talcott Ave Ste 182, Chicago, IL, 60631, USA.
Background: There is limited evidence to inform exercise prescription for deep neck flexor activation out of supine.
Objective: To compare activation of longus colli (LC) and sternocleidomastoid (SCM) from supine to sitting, and to compare the effect of craniocervical flexion (CCF) exercises in sitting on activation.
Methods: Twenty-four individuals without neck pain (mean age 28.
Arts in Medicine for the Reduction of Pain and Stress in Cancer Patients During Chemotherapy.
J Pain Symptom Manage
January 2025
Integrative Medicine, Orlando Health Cancer Institute, Orlando, FL, USA.
Context: Rates of pain and stress are found in greater numbers in cancer patients than in the general population. Cancer patients often are concerned about unwanted side effects that can arise from taking medications to lower their pain and stress. As doctors are reaching for evidence-based, non-pharmaceutical, adjunct modalities, previous research indicates that visual art-making shows promise to help improve perceptions of pain and stress caused by a cancer diagnosis and treatment.
View Article and Find Full Text PDFAnti-Inflammatory and Antioxidant Effects of Aqueous Extract on the Liver and Kidney of PCOS Mice.
J Evid Based Integr Med
January 2025
Department of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon.
Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder associated with increased risk of kidney and liver damage. Current treatments have shown contradictory outcomes, and their long-term use causes unwanted side effects. could serve as a complementary medicine to current PCOS treatments.
View Article and Find Full Text PDFDoes amplitude compression help or hinder attentional neural speech tracking?
J Neurosci
January 2025
Department of Psychology, University of Lübeck, Lübeck, Germany.
Amplitude compression is an indispensable feature of contemporary audio production and especially relevant in modern hearing aids. The cortical fate of amplitude-compressed speech signals is not well-studied, however, and may yield undesired side effects: We hypothesize that compressing the amplitude envelope of continuous speech reduces neural tracking. Yet, leveraging such a 'compression side effect' on unwanted, distracting sounds could potentially support attentive listening if effectively reducing their neural tracking.
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