We propose an 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate human hematopoietic stem cell niches, but also as a drug testing platform for pharmaceutical research and patient-personalized medicine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997254 | PMC |
| http://dx.doi.org/10.1080/23723556.2021.2007030 | DOI Listing |
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