Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for () promoter hypermethylation. We demonstrate that losing in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell identity. These results highlight the importance between transcriptional state, cell of origin, and genetic perturbation in tumorigenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997253 | PMC |
| http://dx.doi.org/10.1080/23723556.2021.2002120 | DOI Listing |
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