Background: Proanthocyanidin has been considered as a preventive agent against erosion because of its properties, which involves remineralization, reduction of demineralization and matrix metalloproteinases (MMPs) inhibition. Thus, the aim of this in situ study was to evaluate the effect of proanthocyanidin-based dentifrices on wear resistance of dentin specimens subjected to erosion associated with abrasion.
Material And Methods: This crossover double-blinded study was performed in 5 phases of 5 days each, with 10 healthy volunteers who wore 5 palatal devices (1 for each phase) with 4 dentin specimens. The groups under study were: G1 - placebo dentifrice (negative control group); G2 - 0.012% chlorhexidine dentifrice (1st positive control group); G3 - NaF 1110 ppm fluoride dentifrice (2nd positive control group); G4 - 10% purified proanthocyanidin dentifrice (1st test group); G5 - fluoride + proanthocyanidin dentifrice (2nd test group). Erosion was performed by palatal device immersion in acid beverage (Coca-cola®), 3 times daily for 5 minutes during 5 days. Abrasion was applied after the first and third erosive cycles by using a eletric toothbrush during 15 seconds in each specimen with the application of the studied dentifrices slurry. The response variable was depth of dentin loss (µm) measured by profilometry. Data were analyzed by Repeated Measures Analysis of Variance followed by LSD Fisher's test (<0.05).
Results: Data (G1: 1.76 ± 0.55A; G2: 1.19 ± 0.42B; G3: 1.29 ± 0.34B; G4: 0.93 ± 0.38C; G5: 0.82 ± 0.34C) showed that G4 and G5 did not presented significant difference between them, but showed less dentine loss when compared to all other groups. G1 presented the highest dentin wear.
Conclusions: Proanthocyanidin and the combination of proanthocyanidin and fluoride dentifrices revealed the best results, showing that these formulations could be a promising alternative for patients who suffer with dentin erosion. Dentin, erosion, cross-liking agent, metalloproteinases, toothpastes.
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http://dx.doi.org/10.4317/jced.59071 | DOI Listing |
Curr Opin Infect Dis
January 2025
Department of Medicine, Clínica Rotger Quironsalud, Palma de Mallorca, Spain.
Purpose Of Review: Optimal duration of therapy in SSTIs - a heterogeneous group of infections - remains unknown. The advances in knowledge of antibiotic duration of treatment in selected SSTIs that can impact clinical practice and published in the last 18 months are reviewed.
Recent Findings: Recent evidence indicates that few patients receive guideline concordant empiric antibiotics and appropriate duration in the United States, although this likely can be extrapolated to other countries.
Clin Infect Dis
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Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Comprehensive Cancer Center, Stockholm, Sweden.
Herpes simplex virus (HSV) infection is one of the most prevalent viral infections worldwide. In general, host immunity is sufficient to clear viral shedding and recurrences, although it is insufficient to prevent subsequent virologic reactivations. In immunocompromised patients, prolonged and difficult-to-treat HSV infections may develop.
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January 2025
Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huai'an, Jiangsu, 223400, China.
: Non-alcoholic fatty liver disease (NAFLD) has become a growing public health problem worldwide, and dietary interventions have important potential in the prevention and treatment of NAFLD. Moreover, previous animal studies have shown that flaxseed has a good improvement effect in animal NAFLD models. : Assess whether flaxseed powder could improve the liver lipid content in patients with NAFLD.
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Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium (D.M.F.v.d.B., E.M.P., E.W., D.C., E.M., B.F., M.V., J.D., K.A.).
Background: Geographic stent-ostium mismatch is an important predictor of target lesion failure after percutaneous coronary intervention of an aorto-ostial right coronary artery lesion. Optimal visualization of the aorto-ostial plane is crucial for precise stent implantation at the level of the ostium. This study investigates whether preprocedural 3-dimensional computed tomography (3DCT), with determination of the optimal viewing angle, would allow for more precise stent implantation and reduce procedure time, contrast, and radiation dose.
View Article and Find Full Text PDFKnee
December 2024
Graduate School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:
Background: In the knee joints of patients with recurrent patellar dislocation (RPD), an increased relative tibial external rotation (rTER) is often observed. However, the changes in this parameter pre- and postoperatively remain unclear.
Purpose: The purpose of this study was to reveal preoperative and postoperative changes in rTER in patients with RPD.
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