Structurally Various Sorbicillinoids From an Endophytic Fungus SS-g13.

Three new sorbicillinoids, including trimer trisorbicillinone E (), acremosorbicillinoids A and B ( and ), and a new alkaloid acremokaloid A (), and a new natural product 2,3-acetyl-β-methyltryptophan (), were isolated from an endophytic fungus SS-g13, which is found in plant root. In addition, eight known sorbicillinoids () were also obtained. The new compound structures were established using NMR, HRESIMS spectra, and reported spectroscopic data. The absolute configurations of compounds , were determined by spectroscopic analysis, Snatzke's method, and time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. Compound exhibited significant cholesterol efflux enhancing activity. A plausible biosynthesis pathway for the sorbicillinoids is discussed.