AI Article Synopsis
- Amantadine hydrochloride and bromocriptine mesylate were tested in a double-blind study to help people withdraw from cocaine dependence, and both showed effectiveness in reducing withdrawal symptoms.
- Bromocriptine caused significant side effects at higher doses, leading to treatment dropouts, while neither drug produced feelings of euphoria.
- Amantadine works by releasing dopamine and norepinephrine from storage sites affected by chronic cocaine use, whereas bromocriptine stimulates dopamine receptors as a dopamine agonist.
Article Abstract
Amantadine hydrochloride and bromocriptine mesylate were compared on a double-blind basis for withdrawal from cocaine dependence. Both amantadine and bromocriptine appear effective in alleviating the symptoms of cocaine withdrawal. In doses higher than previously reported, however, bromocriptine caused enough side effects to produce treatment dropouts; neither drug produced euphoria. Amantadine appears to primarily exert its therapeutic influence by releasing dopamine and norepinephrine from neuronal storage sites that are depleted by chronic cocaine dependence, and bromocriptine acts as a dopamine agonist and stimulates dopamine receptors.
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