Heavy-water-based moderator design for an AB-BNCT unit using a topology optimization algorithm.

. The design of neutron moderators for BNCT treatment units currently relies on parametric approaches, which yield quality results but are ultimately limited by human imagination. Efficient but non-intuitive design solutions may thus be missed out. This limitation needs to be addressed.. To overcome this limitation, we propose to use a topology optimization algorithm coupled with a state-of-the-art Monte-Carlo transport code. This approach recently proved capable of finding complex optimal configurations of particle propagators with limited human intervention.. In this study, we apply this algorithmic solution to optimize some heavy-water neutron moderators for a specific AB-BNCT treatment unit. The moderators thus generated are compact yet succeed in limiting the exposure of patient's healthy tissues to levels below recommended limits. They present subtle, original geometries inaccessible to standard parametric approaches or human intuition.. This approach could be used to automatically fit the design of a BNCT moderator to the location and shape of the tumor or to the morphology of the patient to be treated, opening a path for more targeted BNCT treatment.