AI Article Synopsis

  • The study aimed to evaluate the foveal microvascular structure in children who had retinopathy of prematurity (ROP) and were treated with diode laser photocoagulation, utilizing optical coherence tomography angiography (OCTA).
  • The research involved 17 children with a history of ROP and compared their OCTA results to those of 12 healthy controls, finding significant differences in several parameters.
  • Key findings included a smaller foveal avascular zone and lower vascular density in the ROP group, indicating that OCTA can reveal important long-term changes in macular structures for these patients.

Article Abstract

Background And Objective: To assess the foveal microvascular structure of children with retinopathy of prematurity (ROP) treated with diode laser photocoagulation using optical coherence tomography angiography (OCTA).

Patients And Methods: OCTA was performed at a tertiary medical center in 17 children (27 eyes) aged 4 to 16 years with a history of diode laser photocoagulation treated ROP. OCTA parameters were compared with those of 12 healthy age-matched controls (23 eyes) attending the orthoptics clinic and correlated with clinical factors.

Results: Compared with controls, the ROP group had a smaller foveal avascular zone area ( < .001), lower deep vascular plexus density ( < .001), lower flow density ( = .025), and greater central macular thickness ( < .001). High intraventricular hemorrhage grade correlated with smaller foveal avascular zone area ( = .008) and greater inner macular thickness ( = .047). There was no impact of gestational age, birth weight, or refractive status.

Conclusion: OCTA can identify significant quantifiable long-term macular microvascular and structural changes in this patient population. .

Download full-text PDF

Source
http://dx.doi.org/10.3928/23258160-20220316-02DOI Listing

Publication Analysis

Top Keywords

retinopathy prematurity
8
optical coherence
8
coherence tomography
8
tomography angiography
8
diode laser
8
laser photocoagulation
8
smaller foveal
8
foveal avascular
8
avascular zone
8
zone area
8

Similar Publications

Objective: To evaluate the incidence of thin catheter surfactant administration (TCA) failure and compare short and long-term neonatal outcomes who failed TCA or did not.

Design: Single-center retrospective cohort study. Infants between 25 and 30 weeks of gestational age with respiratory distress syndrome and receiving 200 mg/kg poractant alfa via thin catheter administration were included.

View Article and Find Full Text PDF

Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder that critically affects the visual development of premature infants, potentially leading to irreversible vision loss or even blindness. Despite its significance, the underlying mechanisms of this disease remain insufficiently understood. In this study, we utilized the oxygen-induced retinopathy (OIR) mouse model and conducted endothelial functional assays to explore the role of Sterol Regulatory Element-Binding Protein 1 (SREBF1) in ROP pathogenesis.

View Article and Find Full Text PDF

Background: Very premature infants screened for retinopathy of prematurity (ROP) that do not develop ROP still experience serious visual developmental challenges, and while it is recommended that all children in the UK are offered preschool visual screening, we aimed to explore whether this vulnerable group requires dedicated follow-up.

Methods: We performed a real-world retrospective observational cohort study of children previously screened for ROP in NHS Greater Glasgow and Clyde (Scotland) between 2013 and 2015. We excluded those with any severity of ROP identified during screening.

View Article and Find Full Text PDF

Evaluating the Utility of Initial Exams in Retinopathy of Prematurity: Proposal of FIRST-ROP Algorithm for a Medium-Risk Cohort.

Ophthalmology

January 2025

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. Electronic address:

Purpose: To assess the utility of the first or second examinations for retinopathy of prematurity (ROP) in a medium-risk cohort of infants and to propose an optimization to the current ROP screening guidelines.

Design: Retrospective consecutive study.

Subjects: Infants screened for ROP between January 2017 and August 2023 at three different tertiary-level care neonatal intensive care units.

View Article and Find Full Text PDF

Systemic regulation of retinal medium-chain fatty acid oxidation repletes TCA cycle flux in oxygen-induced retinopathy.

Commun Biol

January 2025

Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA.

Activation of anaplerosis takes away glutamine from the biosynthetic pathways to the energy-producing TCA cycle. Especially, induction of hyperoxia driven anaplerosis in neurovascular tissues such as the retina during early stages of development could deplete biosynthetic precursors from newly proliferating endothelial cells impeding physiological angiogenesis and leading to vasoobliteration. Using an oxygen-induced retinopathy (OIR) mouse model, we investigated the metabolic differences between OIR-resistant BALB/cByJ and OIR susceptible C57BL/6J strains at system levels to understand the molecular underpinnings that potentially contribute to hyperoxia-induced vascular abnormalities in the neural retina.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!