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A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report.
BMC Infect Dis
January 2025
Department of Microbiology and Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan.
Background: Stutzerimonas is a recently proposed genus comprising strains formerly classified as Pseudomonas stutzeri. The genus includes at least 16 identified species. Stutzerimonas nitrititolerans, previously known as Pseudomonas nitrititolerans, was initially isolated from a bioreactor.
View Article and Find Full Text PDF[Investigation of Resistance Nodulation Division (RND) Efflux Pump and OPRD Expression Levels in Antibiotic Resistance of Clinical Pseudomonas aeruginosa Isolates].
Mikrobiyol Bul
October 2024
İnönü University Faculty of Medicine, Deparment of Medical Microbiology, Malatya, Türkiye.
The increasing antibiotic resistance in Pseudomonas aeruginosa, responsible for both community-acquired and hospital-acquired infections, is of global significance. The primary mechanisms contributing to resistance development in P.aeruginosa include the increased activity of efflux pumps, decreased permeability of outer membrane porins and the production of carbapenemases.
View Article and Find Full Text PDFEffect of empiric antibiotics against Pseudomonas aeruginosa on mortality in hospitalized patients: a systematic review and meta-analysis.
J Antimicrob Chemother
December 2024
Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Background: Empiric antibiotics active against Pseudomonas aeruginosa are recommended by professional societies for certain infections and are commonly prescribed for hospitalized patients. The effect of this practice on mortality is uncertain.
Methods: A systematic literature search was conducted using Embase, Medline, PubMed, Web of Science, Cochrane, Scopus and Google Scholar from earliest entry through 9 October 2023.
Article Synopsis
- A gram-negative bacterium commonly found in the environment can lead to severe pneumonia and is linked to cardiovascular complications in hospitalized patients with pneumonia, yet the exact cause of this cardiac dysfunction remains unclear.
- Recent research shows that lung infection causes significant heart issues, but it's not just the overall inflammation that leads to these problems; specific factors from infected immune cells play a key role.
- Exosomes and outer membrane vesicles (OMVs) released during infection have been identified as major contributors to heart problems, with bacterial proteins within them causing contractile dysfunction in heart cells.
Difference of Clinical Manifestation Between Infection and Colonization of Pseudomonas aeruginosa Among Patients With Community-Acquired Pneumonia.
Cureus
November 2024
Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, JPN.
Background: Distinguishing infection and colonization from respiratory samples is challenging. We aimed to determine useful markers for differentiating infection from colonization in community-acquired pneumonia (CAP) patients.
Methods: We included CAP patients in whom was isolated from sputum but were not initially treated with targeting antibiotics.
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