This study aims to assess the resin composite purchases in a public health system and understand the variables associated with its cost and with the decision-making process over a period of 10 years. Secondary data collection was performed using the Brazilian Healthcare Prices Database (BDHP) from 2010 to 2019. All conventional and bulk-fill composites were selected. Date of purchase, institution type and location, procurement modality, number of purchased items, manufacture, and unit prices were collected. A multiple linear regression model assessed the influence of price in the procurement variables, while a multinomial logistic regression compared purchase probabilities between the materials. In total, 18,138 observations were collected with 2,129,294 purchased units and a total cost of USD 43,504,260.00. Conventional composites appeared in 98.5% of the procurement process. Nanofilled conventional composites were the most purchased materials, with an increased probability of purchase over time, despite its higher prices. An increase in prices was predicted for bulk-fill materials when compared to conventional ones. The odds of purchasing this category increased by 3.14x for every price increase over the years. Sociodemographic and type of institution influences the prices and the probability of procurement in the healthcare system. Nanofilled and bulk-fill resin are increasingly included in clinical practice. These findings highlight possible modifications to the standard-of-care in restorative treatments and how the translation of knowledge may occur from the development of new materials to the clinical application considering the economic impact of these modifications.
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http://dx.doi.org/10.1590/0102-311X00118321 | DOI Listing |
J Nanobiotechnology
December 2024
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, JS, 226001, P. R. China.
Peripheral nerve injury poses a significant challenge to the nervous system's regenerative capacity. We previously described a novel approach to construct a chitosan/silk fibroin nerve graft with skin-derived precursor-induced Schwann cells (SKP-SCs). This graft has been shown to promote sciatic nerve regeneration and functional restoration to a level comparable to that achieved by autologous nerve grafts, as evidenced by behavioral, histological, and electrophysiological assessments.
View Article and Find Full Text PDFBMC Oral Health
December 2024
Department of Clinical Dentistry Section of Endodontics, The Faculty of Medicine, University of Bergen, Bergen, Norway.
Background: Toothache is a debilitating condition, often with mild to excruciating pain, swelling, eating difficulties and insomnia. This study aims to delineate the profiles of patients seeking emergency dental care, focusing on the diagnosis, treatment, and outcomes following non-surgical root canal treatment.
Methods: This prospective cohort study was conducted from 2012 to 2021 at the Section for Endodontics, Department of Clinical Dentistry, University of Bergen, Norway.
BMC Musculoskelet Disord
December 2024
Center for Joint Surgery, The First Hospital Affiliated to Army Medical University, Chongqing, 400038, China.
Background: Although chronic quadriceps tendon rupture and defect are rare, they pose significant challenges in surgical treatment. In these cases, quadriceps tendon reconstruction is necessary. Either autologous or allogeneic tendons have been used for this reconstruction.
View Article and Find Full Text PDFApoptosis
December 2024
Department of Respiratory and Critical Care Medicine, WuJin Hospital Afliated With Jiangsu University, WuJin Clinical College of Xuzhou Medical University, No.2, Yongning North Road, Changzhou, 213017, Jiangsu, China.
The treatment of non-small cell lung cancer (NSCLC) remains a critical challenge in oncology, primarily due to the dysfunction and exhaustion of T cells within the tumor microenvironment, which greatly limits the effectiveness of immunotherapy. This study investigates the regulatory role of the T cell immunoglobulin and ITIM domain (TIGIT)-CD226-PVR signaling axis in the exhaustion and apoptosis of cluster of differentiation (CD)27+/CD127+T cells in NSCLC. Utilizing single-cell sequencing technology, we conducted a comprehensive gene expression analysis of T cells in a mouse model of NSCLC.
View Article and Find Full Text PDFCell Mol Life Sci
December 2024
Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, Milan, Italy.
The development of ground-breaking Survival Motor Neuron (SMN) replacement strategies has revolutionized the field of Spinal Muscular Atrophy (SMA) research. However, the limitations of these therapies have now become evident, highlighting the need for the development of complementary targets beyond SMN replacement. To address these challenges, here we explored, in in vitro and in vivo disease models, Stathmin-2 (STMN2), a neuronal microtubule regulator implicated in neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS), as a novel SMN-independent target for SMA therapy.
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