AI Article Synopsis
- * The network includes two key peptides: CKL, which acts like platelets, and CKG, which mimics fibrin, together creating a structure that supports clot formation at injury sites.
- * In tests on rats with severe bleeding, this peptide-based treatment reduced blood loss by 32.8%, indicating its strong potential for use as a trauma hemostatic agent in clinical settings.
Article Abstract
Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an constructable peptide network, mimicking and participating in the native coagulation process for enhanced hemostasis and wound healing. The network consists of two peptides including CKL, mimicking platelets and CKG, mimicking fibrin. The CKL nanoparticles could bind to the collagen at the wound site and transform into CKL nanofibers. The CKG nanoparticles could bind to GPIIb/IIIa receptors on the surface of activated platelets and transform into CKG nanofibers. The formed peptide network could interwind platelets, fibrin and red blood cells, causing embolism at the wound site. In a lethal femoral artery, vein, and nerve cut model of rats, the amount of bleeding was reduced to 32.8% by CKL and CKG with chitosan/alginate. The biomimetic peptides show great clinical potential as trauma hemostatic agents.
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| http://dx.doi.org/10.1039/d2bm00065b | DOI Listing |
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