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Administration of suppresses DSS-induced colitis. | LitMetric
, a filamentous fungus, has long been used for the production of traditional Japanese foods. Here, we analyzed how administration affects the intestinal environment in mice. The results of 16S rRNA gene sequencing of the gut microbiota indicated that after the administration of heat-killed spores, the relative abundance of an anti-inflammatory strain became 2.0-fold greater than that of the control. Next, we examined the effect of spore administration on the development of colitis induced by dextran sodium sulfate in mice; we found that colitis was alleviated by not only heat-killed spores, but also the cell wall extracted from the spores. Our findings suggest that holds considerable potential for commercial application in the production of both traditional Japanese fermented foods and new foods with prebiotic functions.
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