AI Article Synopsis

  • The study examines how sensitive different areas of the adult human head are to diffuse correlation spectroscopy, a technique for monitoring brain blood flow.
  • Researchers used MRI-derived models of sixteen subjects to identify regions with high sensitivity by simulating light propagation across various head locations.
  • Findings reveal that sensitivity varies significantly by location, mainly due to differences in the thickness of tissues outside the brain, which is important for positioning monitoring devices in experiments.

Article Abstract

We characterize cerebral sensitivity across the entire adult human head for diffuse correlation spectroscopy, an optical technique increasingly used for bedside cerebral perfusion monitoring. Sixteen subject-specific magnetic resonance imaging-derived head models were used to identify high sensitivity regions by running Monte Carlo light propagation simulations at over eight hundred uniformly distributed locations on the head. Significant spatial variations in cerebral sensitivity, consistent across subjects, were found. We also identified correlates of such differences suitable for real-time assessment. These variations can be largely attributed to changes in extracerebral thickness and should be taken into account to optimize probe placement in experimental settings.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973189PMC
http://dx.doi.org/10.1364/BOE.449046DOI Listing

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