AI Article Synopsis
- * Researchers used an adenoviral vector to suppress FIZZ1 expression in murine aortic endothelial cells and established a mouse model of atherosclerosis for their experiments.
- * Findings indicate that reducing FIZZ1 expression inhibits inflammatory processes and atherosclerosis development, suggesting FIZZ1 as a potential target for new treatments.
Article Abstract
Objective: Found in Inflammatory Zone 1 (FIZZ1) protein plays an important enhancive role in inflammation and angiogenesis. This study aims to explore the effects of FIZZ1 on murine atherosclerosis.
Methods: The murine aortic endothelial cells were treated with an adenoviral vector encoding FIZZ1 short hairpin RNA (Ad-shFIZZ1). Murine atherosclerosis model was established with ApoE mice. The effects of FIZZ1 were studied and .
Results: Ad-shFIZZ1 treatment suppressed the expression of FIZZ1 and the formation of capillary tube formation . Administration of Ad-shFIZZ1 suppressed FIZZ1-mediated signaling, the growth of endothelial cells and the production of inflammatory molecules in murine aorta , and inhibited the development of atherosclerosis .
Conclusion: FIZZ1 played a potent promotive role in atherosclerosis, and could serve as a novel therapeutic target for the treatment of the disease.
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