Commitment to cellular differentiation programs can be controlled by self-activating transcription factors that trigger the expression of cell-type-specific genes. A new study shows that, although commitment to meiosis in yeast is controlled in this manner, additional signaling interactions promote the committed state.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cub.2022.02.064 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sex specific gene expression is present prior to metamorphosis in the sea urchin.
Dev Biol
January 2025
Department of Molecular, Cellular Biology and Biochemistry, BioMed Division, Brown University, 185 Meeting Street, Providence, RI, 02912, USA. Electronic address:
A profound collaboration between the germline and somatic cells of an organism is the creation of a functional gonad. Here we establish a foundation for studying molecular gonadogenesis in the sea urchin by use of RNA-seq, quantitative mRNA measurements, and in-situ hybridizations throughout the life cycle of the variegated sea urchin, Lytechinus variegatus (Lv). We found through three distinct analyses that the ovary and testis of this echinoderm expresses unique transcripts involved in gametogenesis, and also discovered uncharacterized gene products unique to each gonad.
View Article and Find Full Text PDFFemale-specific mechanisms of meiotic initiation and progression in mammalian oocyte development.
Genes Cells
October 2024
Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan.
Article Synopsis
- Meiosis in mammals is regulated differently for males and females, with females entering meiosis during fetal development and pausing until puberty.
- The precise genetic mechanisms that control oocyte development and meiosis in females are not fully understood, though meiosis initiation involves a common mechanism activated by STRA8.
- The review focuses on the unique interplay between retinoblastoma (RB) and STRA8 in females, which influences the timing of meiotic entry and potential arrest during oocyte development.
Retinoic acid tiers mitochondrial metabolism to Sertoli Cell-Mediated efferocytosis via a non-RAR-dependent mechanism.
Biochem Pharmacol
July 2024
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226001, China; School of Basic Medical Sciences, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004, China. Electronic address:
Efferocytosis of massive non-viable germ cells by Sertoli cells (SCs), the specialized phagocytes, is essential for maintaining testis homeostasis. What elusive is the contribution of mitochondrial metabolism to this energy-consuming process, as SC has a preference of aerobic glycolysis. All-trans retinoic acid (ATRA, hereafter referred to as RA) is a well-known morphogen that primarily acts through the nuclear RA receptor (RAR).
View Article and Find Full Text PDFInsights into the identification and evolutionary conservation of key genes in the transcriptional circuits of meiosis initiation and commitment in budding yeast.
FEBS Open Bio
December 2023
Computational and Systems Biology Laboratory, Department of Microbiology, Raiganj University, India.
Initiation of meiosis in budding yeast does not commit the cells for meiosis. Thus, two distinct signaling cascades may differentially regulate meiosis initiation and commitment in budding yeast. To distinguish between the role of these signaling cascades, we reconstructed protein-protein interaction networks and gene regulatory networks with upregulated genes in meiosis initiation and commitment.
View Article and Find Full Text PDFEvidence for RA-dependent meiosis onset in a turtle embryo.
Cell Tissue Res
October 2023
College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, 315100, China.
Meiotic entry is one of the earliest sex determination events of the germ cell in higher vertebrates. Although advances in meiosis onset have been achieved in mammals, birds and fish, how this process functions in reptiles is largely unknown. In this study, we present the molecular analysis of meiosis onset and the role of retinoic acid (RA) in this process in the red-eared slider turtle.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!