To achieve reliable and automatic anomaly detection (AD) for large equipment such as liquid rocket engine (LRE), multisource data are commonly manipulated in deep learning pipelines. However, current AD methods mainly aim at single source or single modality, whereas existing multimodal methods cannot effectively cope with a common issue, modality incompleteness. To this end, we propose an unsupervised multimodal method for AD with missing sources in LRE system. The proposed method handles intramodality fusion, intermodality fusion, and decision fusion in a unified framework composed of multiple deep autoencoders (AEs) and a skip-connected AE. Specifically, the first module restores missing sources to construct a complete modality, thus advancing the secondary reconstruction. Different from vanilla reconstruction-based methods, the proposed method minimizes reconstruction loss and meanwhile maximizes the dissimilarity of representations in two latent spaces. Utilizing reconstruction errors and latent representation discrepancy, the anomaly score is acquired. At decision level, the model performance can be further enhanced via anomaly score fusion. To demonstrate the effectiveness, extensive experiments are carried out on multivariate time-series data from static ignition of several LREs. The results indicate the superiority and potential of the proposed method for AD with missing sources for LRE.
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http://dx.doi.org/10.1109/TNNLS.2022.3162949 | DOI Listing |
Nat Methods
January 2025
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Teravoxel-scale, cellular-resolution images of cleared rodent brains acquired with light-sheet fluorescence microscopy have transformed the way we study the brain. Realizing the potential of this technology requires computational pipelines that generalize across experimental protocols and map neuronal activity at the laminar and subpopulation-specific levels, beyond atlas-defined regions. Here, we present artficial intelligence-based cartography of ensembles (ACE), an end-to-end pipeline that employs three-dimensional deep learning segmentation models and advanced cluster-wise statistical algorithms, to enable unbiased mapping of local neuronal activity and connectivity.
View Article and Find Full Text PDFBioinform Adv
January 2025
Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, D-69120 Heidelberg, Germany.
Motivation: Since their introduction about 10 years ago, methylation clocks have provided broad insights into the biological age of different species, tissues, and in the context of several diseases or aging. However, their application to single-cell methylation data remains a major challenge, because of the inherent sparsity of such data, as many CpG sites are not covered. A methylation clock applicable on single-cell level could help to further disentangle the processes that drive the ticking of epigenetic clocks.
View Article and Find Full Text PDFSci Rep
January 2025
Faculty of Engineering, Université de Moncton, Moncton, NB, E1A3E9, Canada.
Diabetes is a growing health concern in developing countries, causing considerable mortality rates. While machine learning (ML) approaches have been widely used to improve early detection and treatment, several studies have shown low classification accuracies due to overfitting, underfitting, and data noise. This research employs parallel and sequential ensemble ML approaches paired with feature selection techniques to boost classification accuracy.
View Article and Find Full Text PDFViruses
December 2024
Life Sciences, Health, and Engineering Department, The Roux Institute, Northeastern University, Portland, ME 04101, USA.
JC polyomavirus (JCPyV) establishes a persistent, asymptomatic kidney infection in most of the population. However, JCPyV can reactivate in immunocompromised individuals and cause progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease with no approved treatment. Mutations in the hypervariable non-coding control region (NCCR) of the JCPyV genome have been linked to disease outcomes and neuropathogenesis, yet few metanalyses document these associations.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
School of Biological Sciences and The Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Sphingolipidomic mass spectrometry has provided valuable information-and surprises-about sphingolipid structures, metabolism, and functions in normal biological processes and disease. Nonetheless, many noteworthy compounds are not routinely determined, such as the following: most of the sphingoid bases that mammals biosynthesize de novo other than sphingosine (and sometimes sphinganine) or acquire from exogenous sources; infrequently considered metabolites of sphingoid bases, such as N-(methyl)-derivatives; "ceramides" other than the most common N-acylsphingosines; and complex sphingolipids other than sphingomyelins and simple glycosphingolipids, including glucosyl- and galactosylceramides, which are usually reported as "monohexosylceramides". These and other subspecies are discussed, as well as some of the circumstances when they are likely to be seen (or present and missed) due to experimental conditions that can influence sphingolipid metabolism, uptake from the diet or from the microbiome, or as artifacts produced during extraction and analysis.
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