AI Article Synopsis
- * Recent findings indicate a more powerful action of cocaine, suggesting the existence of a high-affinity receptor for cocaine, specifically associated with brain acid soluble protein 1 (BASP1).
- * Knocking down BASP1 in the striatum reduces cocaine binding and depleting it in the nucleus accumbens decreases locomotion in mice, indicating BASP1's importance as a receptor for cocaine.
Article Abstract
Cocaine exerts its stimulant effect by inhibiting dopamine (DA) reuptake, leading to increased dopamine signaling. This action is thought to reflect the binding of cocaine to the dopamine transporter (DAT) to inhibit its function. However, cocaine is a relatively weak inhibitor of DAT, and many DAT inhibitors do not share cocaine’s behavioral actions. Further, recent reports show more potent actions of the drug, implying the existence of a high-affinity receptor for cocaine. We now report high-affinity binding of cocaine associated with the brain acid soluble protein 1 (BASP1) with a dissociation constant (Kd) of 7 nM. Knocking down BASP1 in the striatum inhibits [3H]cocaine binding to striatal synaptosomes. Depleting BASP1 in the nucleus accumbens but not the dorsal striatum diminishes locomotor stimulation in mice. Our findings imply that BASP1 is a pharmacologically relevant receptor for cocaine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169839 | PMC |
| http://dx.doi.org/10.1073/pnas.2200545119 | DOI Listing |
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