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Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice. | LitMetric

AI Article Synopsis

  • - The health impacts of conventional tobacco are clear, but the effects of flavored e-cigarettes, like JUUL, particularly with their high nicotine content, are less understood, despite evidence of inflammatory changes in the body.
  • - A study found that 3 months of inhaling JUUL aerosols increased inflammatory markers in the brain, lungs, heart, and colon, indicating significant gene expression changes linked to neuroinflammation and gut inflammation.
  • - These inflammatory responses not only suggest a potential link to mood disorders and behavior changes but also indicate increased risks for cardiovascular disease and overall poor health due to e-cigarette use.

Article Abstract

While health effects of conventional tobacco are well defined, data on vaping devices, including one of the most popular e-cigarettes which have high nicotine levels, are less established. Prior acute e-cigarette studies have demonstrated inflammatory and cardiopulmonary physiology changes while chronic studies have demonstrated extra-pulmonary effects, including neurotransmitter alterations in reward pathways. In this study we investigated the impact of inhalation of aerosols produced from pod-based, flavored e-cigarettes (JUUL) aerosols three times daily for 3 months on inflammatory markers in the brain, lung, heart, and colon. JUUL aerosol exposure induced upregulation of cytokine and chemokine gene expression and increased HMGB1 and RAGE in the nucleus accumbens in the central nervous system. Inflammatory gene expression increased in the colon, while gene expression was more broadly altered by e-cigarette aerosol inhalation in the lung. Cardiopulmonary inflammatory responses to acute lung injury with lipopolysaccharide were exacerbated in the heart. Flavor-specific findings were detected across these studies. Our findings suggest that daily e-cigarette use may cause neuroinflammation, which may contribute to behavioral changes and mood disorders. In addition, e-cigarette use may cause gut inflammation, which has been tied to poor systemic health, and cardiac inflammation, which leads to cardiovascular disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005188PMC
http://dx.doi.org/10.7554/eLife.67621DOI Listing

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