AI Article Synopsis
- Three new polyacetylenes, named pellynols P (1), Q (2), and R (3), were discovered in the marine sponge Petrosia sp., alongside the already known pellynol H (4).
- Researchers determined the structures of these compounds using advanced techniques like NMR, HR-MS, and ESI-MS/MS.
- All four compounds showed strong cytotoxic effects against various cancer cell lines, with IC values ranging from 1.4 to 4.4 μM, indicating their potential as cancer treatments.
Article Abstract
Three new polyacetylenes, pellynols P (1), Q (2), and R (3) were isolated from the marine sponge Petrosia sp., along with the known compound pellynol H (4). Their structures were determined by analyses of extensive NMR, HR-MS, and ESI-MS/MS data. All compounds displayed potent cytotoxicities against human hepatocellular carcinoma HepG2, human melanoma A375, and human colorectal carcinoma HT29 cell lines with IC values at the range of 1.4-4.4 μM.
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| http://dx.doi.org/10.1002/cbdv.202200159 | DOI Listing |
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