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Phytometabolites, Pharmacological Effects, Ethnomedicinal Properties, and Bioeconomic Potential of Velvet Apple (Diospyros discolor Willd.): A Review.
Chem Biodivers
January 2025
Liverpool John Moores University, Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Diospyros discolor Willd., commonly known as Velvet apple or Mabolo, is an underutilized fruit. Traditionally, various parts of D.
View Article and Find Full Text PDFUsing DNA metabarcoding and direct behavioural observations to identify the diet of proboscis monkeys (Nasalis larvatus) in the Kinabatangan Floodplain, Sabah.
PLoS One
January 2025
Danau Girang Field Centre, c/o Sabah Wildlife Department, Kota Kinabalu, Malaysia.
Characterizing the feeding ecology of threatened species is essential to establish appropriate conservation strategies. We focused our study on the proboscis monkey (Nasalis larvatus), an endangered primate species which is endemic to the island of Borneo. Our survey was conducted in the Lower Kinabatangan Wildlife Sanctuary (LKWS), a riverine protected area that is surrounded by oil palm plantations.
View Article and Find Full Text PDFTurning the spotlight: Hostile behavior in creative higher education and links to mental health in marginalized groups.
PLoS One
January 2025
Research Unit Gender in Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Hostile, discriminatory, and violent behavior within the creative industries has attracted considerable public interest and existing inequalities have been discussed broadly. However, few empirical studies have examined experiences of hostile behavior in creative higher education and associated mental health outcomes of early career artists. To address this gap, we conducted a survey among individuals studying at higher education institutions for art and music (N = 611).
View Article and Find Full Text PDFFast exact gap-affine partial order alignment with POASTA.
Bioinformatics
January 2025
Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Motivation: Partial order alignment is a widely used method for computing multiple sequence alignments, with applications in genome assembly and pangenomics, among many others. Current algorithms to compute the optimal, gap-affine partial order alignment do not scale well to larger graphs and sequences. While heuristic approaches exist, they do not guarantee optimal alignment and sacrifice alignment accuracy.
View Article and Find Full Text PDFFunctionalization of Pyridines at the C4 Position via Metalation and Capture.
Angew Chem Int Ed Engl
January 2025
Texas A&M University, Chemistry, UNITED STATES OF AMERICA.
The functionalization of pyridines at positions remote to the N-atom remains an outstanding problem in organic synthesis. The inherent challenges associated with overriding the influence of the embedded N-atom within pyridines was overcome using n-butylsodium, which provided an avenue to deprotonate and functionalize the C4-position over traditionally observed addition products that are formed with organolithium bases. In this work, we show that freshly generated 4-sodiopyrdines could undergo transition metal free alkylation reactions directly with a variety of primary alkyl halides bearing diverse functional groups.
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