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Elimination of receptor binding by influenza hemagglutinin improves vaccine-induced immunity. | LitMetric

AI Article Synopsis

Article Abstract

The binding of influenza hemagglutinin (HA) to sialic acid (SA) receptors plays a well-defined role in shaping infection but the impact of such binding on vaccine responses has not yet been explored. We generated a virus-like particle (VLP) vaccine bearing the HA of H1N1 A/California/07/09 that is unable to bind to its α(2,6)-linked SA receptor (H1-VLP) and compared its immunogenicity and efficacy to a wild-type H1-VLP (H1-VLP) in mice. The H1-VLP elicited significantly stronger and more durable antibody responses (hemagglutination inhibition and microneutralization titers) and greater avidity maturation, likely attributable to improved germinal center formation. H1-VLP also resulted in a robust population of IL-2TNFαIFNγ CD4 T cells that correlated with antibody responses. Compared to H1-VLP vaccination, mice immunized with H1-VLP had 2.3-log lower lung viral loads and significantly lower pulmonary inflammatory cytokine levels 5 days post-challenge. These findings suggest that abrogation of HA-SA interactions may be a promising strategy to improve the quality and durability of influenza vaccine-induced humoral responses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001741PMC
http://dx.doi.org/10.1038/s41541-022-00463-3DOI Listing

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