AI Article Synopsis
- Lysine methyltransferase 2C (KMT2C) is identified as a tumor-suppressor gene linked to various cancers, including oral cancer through specific genetic variations called single-nucleotide polymorphisms (SNPs).
- The study analyzed five KMT2C SNPs in 284 cancer-free controls and 284 oral squamous cell carcinoma cases, highlighting that the TC or TC + CC genotypes of rs4725443 correlate with a higher risk of oral cancer.
- Additional findings suggest that this SNP genotype is associated with more advanced tumor stages and poorer cell differentiation, making KMT2C SNP rs4725443 a potential genetic marker for oral cancer risks in different drinking populations.
Article Abstract
Lysine methyltransferase 2C (KMT2C) is a tumor-suppressor gene in several myeloid cells and epithelia and is linked with blood and solid tumor cancers. KMT2C single-nucleotide polymorphisms (SNPs) are also connected with several cancer types. Our study aimed to explore the potential genetic polymorphisms of KMT2C in oral cancer. Five KMT2C SNPs, including rs201834857, rs4725443, rs6464221, rs74483926, and rs6943984, were evaluated in 284 cancer-free controls and 284 oral squamous cell carcinoma (OSCC) cases. We found that individuals with the TC genotype or TC + CC genotype of rs4725443 had a higher risk of oral cancer incidence than those with the TT genotype. Further analysis of KMT2C SNP rs4725443 revealed that the TC + CC genotype of rs4725443 was associated with a significantly advanced tumor stage in the non-alcohol-drinking population. Moreover, the TC + CC genotype of rs4725443 was connected with poor cell differentiation in the alcohol-drinking population. Through analyzing a dataset from The Cancer Genome Atlas (TCGA), we found that reduced KMT2C levels were associated with advanced tumor stage, lymph node invasion, and poor cell differentiation in head and neck squamous cell carcinomas. Our data suggest that KMT2C SNP rs4725443 is a potential genetic marker for oral cancer patients in both non-alcohol-drinking and alcohol-drinking populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997509 | PMC |
| http://dx.doi.org/10.3390/ijerph19073974 | DOI Listing |
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