AI Article Synopsis
- * Current pharmaceutical options for managing viral infections after HSCT have significant limitations, highlighting the need for better strategies.
- * Adoptive cell therapy (ACT) is an emerging approach that aims to enhance the immune response to infections in post-HSCT patients, with reported success in three pediatric cases experiencing central nervous system complications after donor lymphocyte infusion.
Article Abstract
Early post-transplant is the critical phase for the success of hematopoietic stem cell transplantation (HSCT). New viral infections and the reactivations associated with complete ablation of the recipient's T-cell immunity and inefficient reconstitution of the donor-derived system represent the main risks of HSCT. To date, the pharmacological treatments for post-HSCT viral infection-related complications have many limitations. Adoptive cell therapy (ACT) represents a new pharmacological strategy, allowing us to reconstitute the immune response to infectious agents in the post-HSC period. To demonstrate the potential advantage of this novel immunotherapy strategy, we report three cases of pediatric patients and the respective central nervous system complications after donor lymphocyte infusion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998460 | PMC |
| http://dx.doi.org/10.3390/ijms23073553 | DOI Listing |
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