Three -terphenyls (-)-2-hydroxy-3,5-dimethoxy--terphenyl (), 2-hydroxy-3,6-dimethoxy--terphenyl (), and 2,3,5,6-tetramethoxy--terphenyl ()-were isolated for the first time as natural products along with seven known compounds (, -) from the Antarctic lichen Structures of the new compounds were elucidated by comprehensive analyses of 1D and 2D NMR and HREIMS experiments. Compound exhibited cytotoxicity against HCT116 cells with the IC value of 3.76 ± 0.03 μM and also inhibited NO production in LPS-induced RAW264.7 macrophages with the IC value of 22.82 ± 0.015 μM.
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http://dx.doi.org/10.3390/molecules27072363 | DOI Listing |
Polar Biol
October 2024
Research Department for Limnology, Universität Innsbruck, 5310 Mondsee, Austria.
Unlabelled: The diversity of bacteria associated with lichens has received increasing attention. However, studies based on next-generation sequencing of microbiomes have not yet been conducted in the Arctic and Subarctic regions. In this study, rock-dwelling lichens belonging to the Umbilicariaceae family were sampled from the Arctic and Subarctic biological zones.
View Article and Find Full Text PDFMolecules
November 2024
Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Republic of Korea.
Alzheimer's disease (AD) remains a significant public health challenge with limited effective treatment options. Ramalin, a compound derived from Antarctic lichens, has shown potential in the treatment of AD because of its strong antioxidant and anti-inflammatory properties. However, its instability and toxicity have hindered the development of Ramalin as a viable therapeutic agent.
View Article and Find Full Text PDFBiochem Pharmacol
January 2025
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, South Korea. Electronic address:
Ramalin, a strong antioxidant isolated from Antarctic lichens, has been shown to have potential therapeutic effects in the treatment of Alzheimer's disease. However, this compound is readily degraded in aqueous solutions, which restricts its development as a therapeutic agent. With a view toward addressing this problem, in this study, we modified the structure of ramalin to obtain more stable compounds and attempted to identify a derivative with the strongest neuroprotective properties.
View Article and Find Full Text PDFIn the Antarctic, Arctic, and Tibetan Plateau-recognized as the Earth's three poles characterized by extremely harsh environments-lichens prevail in the ecosystem and play crucial roles as pioneer species. Despite their importance, studies investigating the spatial distribution patterns of lichen attributes are scarce due to a lack of appropriate datasets. To bridge this gap and enhance our understanding of the growth preferences of lichens in these areas, here we present a geospatial dataset encompassing key attributes of lichens, such as color type and growth form, for over 2800 lichen species and 170,000 in-situ lichen records.
View Article and Find Full Text PDFCurr Biol
November 2024
Centro de Estudos Geográficos, Laboratório Associado TERRA, Instituto de Geografia e Ordenamento do Território, Universidade de Lisboa, 1600-276 Lisboa, Portugal.
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