This paper presents a plantar pressure sensor system (P2S2) integrated in the insoles of shoes to detect thirteen commonly used human movements including walking, stooping left and right, pulling a cart backward, squatting, descending, ascending stairs, running, and falling (front, back, right, left). Six force sensitive resistors (FSR) sensors were positioned on critical pressure points on the insoles to capture the electrical signature of pressure change in the various movements. A total of 34 adult participants were tested with the P2S2. The pressure data were collected and processed using a Principal Component Analysis (PCA) for input to the multiple machine learning (ML) algorithms, including k-NN, neural network and Support-Vector Machine (SVM) algorithms. The ML models were trained using four-fold cross-validation. Each fold kept subject data independent from other folds. The model proved effective with an accuracy of 86%, showing a promising result in predicting human movements using the P2S2 integrated in shoes.
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http://dx.doi.org/10.3390/s22072743 | DOI Listing |
Front Immunol
January 2025
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
The innate immune system promptly detects and responds to invading pathogens, with a key role played by the recognition of bacterial-derived DNA through pattern recognition receptors. The Z-DNA binding protein 1 (ZBP1) functions as a DNA sensor inducing type I interferon (IFN) production, innate immune responses and also inflammatory cell death. ZBP1 interacts with cytosolic DNA via its DNA-binding domains, crucial for its activation.
View Article and Find Full Text PDFBMJ Neurol Open
January 2025
Neurological Surgery, Mount Sinai Health System, New York, New York, USA.
Background: Early diagnosis of degenerative cervical myelopathy (DCM) is often challenging due to subtle, non-specific symptoms, limited disease awareness and a lack of definitive diagnostic criteria. As primary care physicians are typically the first to encounter patients with early DCM, equipping them with effective screening tools is crucial for reducing diagnostic delays and improving patient outcomes. This systematic review evaluates the efficacy of quantitative screening methods for DCM that can be implemented in primary care settings.
View Article and Find Full Text PDFFront Neurosci
January 2025
The Basic Department, The Tourism College of Changchun University, Changchun, China.
Introduction: In the field of medical listening assessments,accurate transcription and effective cognitive load management are critical for enhancing healthcare delivery. Traditional speech recognition systems, while successful in general applications often struggle in medical contexts where the cognitive state of the listener plays a significant role. These conventional methods typically rely on audio-only inputs and lack the ability to account for the listener's cognitive load, leading to reduced accuracy and effectiveness in complex medical environments.
View Article and Find Full Text PDFFront Digit Health
January 2025
Khoury College of Computer Sciences and Bouvé College of Health Sciences, Northeastern University, Boston, MA, United States.
Smartphones and wearable sensors offer an unprecedented ability to collect peripheral psychophysiological signals across diverse timescales, settings, populations, and modalities. However, open-source software development has yet to keep pace with rapid advancements in hardware technology and availability, creating an analytical barrier that limits the scientific usefulness of acquired data. We propose a community-driven, open-source peripheral psychophysiological signal pre-processing and analysis software framework that could advance biobehavioral health by enabling more robust, transparent, and reproducible inferences involving autonomic nervous system data.
View Article and Find Full Text PDFThis study presents the characterization of a novel multilayered three-dimensional (3D) polymer exhibiting aggregation-induced emission (AIE) properties when excited at a low wavelength of 280 nm. Utilizing fluorescence spectroscopy, we demonstrate that the polymer displays a marked enhancement in luminescence upon aggregation, a characteristic behavior that distinguishes AIE-active materials from conventional fluorophores. Furthermore, we explore the potential application of this multilayered 3D polymer as a fluorescent probe for the selective detection of specified metal ions.
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