This work presents the features of the PABIG 3D polymer gel dosimeter. It consists of two cross-linkers: poly(ethylene glycol) diacrylate (PEGDA), as one biacrylic component, and ,'-methylenebisacrylamide (MBA), which is another cross-linker often used in 3D dosimeters. Additionally, it contains oxygen scavenges of copper sulfate pentahydrate and ascorbic acid. All ingredients are embedded in a physical gel matrix of gelatine. Upon irradiation, the biacrylic cross-linking agents (PEGDA and MBA) undergo radical polymerisation and cross-linking, which is manifested by the appearance of the opacity of the intensity related to the absorbed dose. PABIG was irradiated with an oncological source of ionising radiation, and analysed by using a nuclear magnetic resonance (0.5 T). The following characteristics were obtained: (i) linear and dynamic dose-response of 0.5 to ~18 Gy and 40 Gy, respectively, (ii) dose sensitivity of 0.071 ± 0.001 Gy s, (iii) integral 3D dose distribution for at least 24 days after irradiation, (iv) adequate batch-to-batch reproducibility, (v) dose-response independent of irradiation with 6 MV photons, 15 MV photons, 6 MV photons FFF of 0.0168-0.1094 Gy/s dose rates, and (vi) soft tissue equivalence. The study showed that the features of PABIG confirm its suitability for use in 3D radiotherapy dosimetry.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999682 | PMC |
http://dx.doi.org/10.3390/ma15072550 | DOI Listing |
Materials (Basel)
March 2022
Department of Radiotherapy Planning, Copernicus Hospital, 90-543 Lodz, Poland.
This work presents the features of the PABIG 3D polymer gel dosimeter. It consists of two cross-linkers: poly(ethylene glycol) diacrylate (PEGDA), as one biacrylic component, and ,'-methylenebisacrylamide (MBA), which is another cross-linker often used in 3D dosimeters. Additionally, it contains oxygen scavenges of copper sulfate pentahydrate and ascorbic acid.
View Article and Find Full Text PDFPhys Med Biol
August 2014
GeVero Co., Tansmana St. 2/11, 92-548 Lodz, Poland.
The subject of this work is polyGeVero(®) software (GeVero Co., Poland), which has been developed to fill the requirements of fast calculations of 3D dosimetry data with the emphasis on polymer gel dosimetry for radiotherapy. This software comprises four workspaces that have been prepared for: (i) calculating calibration curves and calibration equations, (ii) storing the calibration characteristics of the 3D dosimeters, (iii) calculating 3D dose distributions in irradiated 3D dosimeters, and (iv) comparing 3D dose distributions obtained from measurements with the aid of 3D dosimeters and calculated with the aid of treatment planning systems (TPSs).
View Article and Find Full Text PDFActa Phys Pol A
November 2012
Faculty of Physics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland.
Sophisticated techniques employed in radiotherapy for irradiation of tumours require comprehensive dosimetry allowing for precise, high resolution measurements of radiation dose distribution in three dimensions and verification of treatment planning systems. Polymer gel dosimetry has been shown to be a unique technique for three-dimensional high resolution measurements of absorbed radiation dose distributions. If exposed to ionizing radiation, radical polymerisation and crosslinking of monomeric components take place in a 3D polymer gel dosimeter, leading to the formation of large polymeric structures that scatter visible light.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!