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Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration. | LitMetric

AI Article Synopsis

  • - Curcumin (CUR) and quercetin (QU) show promise in treating neurodegenerative diseases due to their anti-inflammatory and antioxidant properties, but their effectiveness is limited by low water solubility and poor bioavailability.
  • - This study explores the use of omega-3 fatty acid nanoemulsions (NEs) loaded with CUR and QU, prepared via two methods for intranasal administration, revealing that both methods produced stable formulations but showed differences in size and release characteristics.
  • - High-pressure homogenization (HPH) was identified as the superior method, resulting in a nanoemulsion that demonstrated potential for sustained release of the compounds, while toxicity tests indicated that the formulations were not harmful, suggesting improved delivery for

Article Abstract

Curcumin (CUR) and quercetin (QU) are potential compounds for treatment of brain diseases such as neurodegenerative diseases (ND) because of their anti-inflammatory and antioxidant properties. However, low water solubility and poor bioavailability hinder their clinical use. In this context, nanotechnology arises as a strategy to overcome biopharmaceutical issues. In this work, we develop, characterize, compare, and optimize three different omega-3 (ω-3) fatty acids nanoemulsions (NEs) loaded with CUR and QU (negative, cationic, gelling) prepared by two different methods for administration by intranasal route (IN). The results showed that formulations prepared with the two proposed methods exhibited good stability and were able to incorporate a similar amount of CUR and QU. On the other side, differences in size, zeta potential, in vitro release kinetics, and permeation/retention test were observed. Considering the two preparation methods tested, high-pressure homogenization (HPH) shows advantages, and the CQ NE- obtained demonstrated potential for sustained release. Toxicity studies demonstrated that the formulations were not toxic for . The developed ω-3 fatty acid NEs have shown a range of interesting properties for the treatment of brain diseases, since they have the potential to increase the nose-to-brain permeation of CUR and QU, enabling enhanced treatments efficiency.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000715PMC
http://dx.doi.org/10.3390/nano12071073DOI Listing

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