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Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study. | LitMetric

AI Article Synopsis

  • - Health-related quality of life (HRQoL) in patients treated for metastatic colorectal cancer (mCRC) showed high scores during curative treatment phases, with mean values indicating good well-being compared to the general Finnish population.
  • - The RAXO-study utilized several HRQoL questionnaires to assess patient outcomes, revealing improvements in HRQoL during remission phases, where scores were similar to healthy individuals after over 18 months without disease.
  • - Despite initially high HRQoL during treatments aimed at cure, patients experienced a notable decline in quality of life when treatment shifted away from curative intent, affected predominantly by symptoms like insomnia, impotence, and fatigue.

Article Abstract

Metastasectomy and/or local ablative therapy in metastatic colorectal cancer (mCRC) patients often provide long-term survival. Health-related quality of life (HRQoL) data in curatively treated mCRC are limited. In the RAXO-study that evaluated repeated resectability, a multi-cross-sectional HRQoL substudy with 15D, EQ-5D-3L, QLQ-C30, and QLQ-CR29 questionnaires was conducted. Mean values of patients in different treatment groups were compared with age- and gender-standardized general Finnish populations. The questionnaire completion rate was 444/477 patients (93%, 1751 questionnaires). Mean HRQoL was 0.89−0.91 with the 15D, 0.85−0.87 with the EQ-5D, 68−80 with the EQ-5D-VAS, and 68−79 for global health status during curative treatment phases, with improvements in the remission phase (disease-free >18 months). In the remission phase, mean EQ-5D and 15D scores were similar to the general population. HRQoL remained stable during first- to later-line treatments, when the aim was no longer cure, and declined notably when tumour-controlling therapy was no longer meaningful. The symptom burden affecting mCRC survivors’ well-being included insomnia, impotence, urinary frequency, and fatigue. Symptom burden was lower after treatment and slightly higher, though stable, through all phases of systemic therapy. HRQoL was high in curative treatment phases, further emphasizing the strategy of metastasectomy in mCRC when clinically meaningful.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996978PMC
http://dx.doi.org/10.3390/cancers14071713DOI Listing

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