Resurgence occurs when a previously reinforced and then extinguished target response increases due to a worsening of reinforcement conditions for an alternative response. We conducted four crowdsourcing experiments to evaluate effects of alternative-reinforcer rate and magnitude on resurgence with humans. Contingent on an alternative response, we manipulated across groups either the rate of point delivery (Experiment 1) or number of points delivered per reinforcer (Experiments 2-3). Experiment 4 arranged combinations of high- or low-rate and high- or low-magnitude alternative reinforcement across four groups. When extinguishing alternative responding across experiments, we observed resurgence of target responding with relatively high rates of alternative reinforcement but differences in reinforcer magnitude did not influence resurgence. A quantitative model based on the concatenated matching law, Resurgence as Choice in Context (RaC), provided a poor fit to the data, generally underpredicted target responding, and could not account for data from control groups experiencing extinction of target responding in the absence of alternative reinforcement. We then fit a modified version of RaC borrowing an assumption from theories of choice that suggest some proportion of reinforcers are misallocated between responses - this modified version of RaC provided a better account of these findings.
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http://dx.doi.org/10.1016/j.beproc.2022.104641 | DOI Listing |
Sci Rep
January 2025
Business School, Sichuan University, 610059, Chengdu, China.
The comprehensive benefit evaluation of LID based on multi-criteria decision-making methods faces technical issues such as the uncertainties and vagueness in hybrid information sources, which can affect the overall evaluation results and ranking of alternatives. This study introduces a multi-indicator fuzzy comprehensive benefit evaluation approach for the selection of LID measures, aiming to provide a robust and holistic framework for evaluating their benefits at the community level. The proposed methodology integrates quantitative environmental and economic indicators with qualitative social benefit indicators, combining the use of the Storm Water Management Model (SWMM) and ArcGIS for scenario-based analysis, and the use of hesitant fuzzy language sets and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) for decision-making.
View Article and Find Full Text PDFAAPS J
January 2025
Moderna, Inc., Cambridge, Massachusetts, USA.
While the branched DNA (bDNA) assay is an established bioanalytical method for measurement of lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) pharmacokinetic parameters, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) has been considered as an alternative platform. RT-qPCR and bDNA platforms were compared for sensitivity, specificity, correlation, and overall assay performance using serum and tissue samples from 2 nonclinical mouse studies of a therapeutic mRNA candidate, LNP-PAH-mRNA, which encodes for human phenylalanine hydroxylase enzyme. Pharmacokinetic parameter noncompartmental analysis was completed using Phoenix WinNonlin.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Economics and Business (ICADE), Universidad Pontificia Comillas, Madrid, Spain.
Financial portfolio management investment policies computed quantitatively by modern portfolio theory techniques like the Markowitz model rely on a set of assumptions that are not supported by data in high volatility markets such as the technological sector or cryptocurrencies. Hence, quantitative researchers are looking for alternative models to tackle this problem. Concretely, portfolio management (PM) is a problem that has been successfully addressed recently by Deep Reinforcement Learning (DRL) approaches.
View Article and Find Full Text PDFMol Autism
January 2025
Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Background: Risk preference changes nonlinearly across development. Although extensive developmental research on the neurotypical (NTP) population has shown that risk preference is highest during adolescence, developmental changes in risk preference in autistic (AUT) people, who tend to prefer predictable behaviors, have not been investigated. Here, we aimed to investigate these changes and underlying computational mechanisms.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
State Key Laboratory of Biobased Fiber Manufacturing Technology, China Light Industry Key Laboratory of Papermaking and Biorefinery, Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address:
Exploring innovative and sustainable routes for the production of biodegradable biomass-based materials is critical to promote a circular carbon economy and carbon neutrality goals. Fossil-based non-biodegradable plastic waste poses a nonnegligible threat to humans and the ecological environment, and biomass-based functional materials are becoming increasingly viable alternatives. Lignin, a naturally occurring macromolecular polymer, is green and renewable resource rich in aromatic rings, with biodegradability, biocompatibility, and excellent processability for eco-friendly composites.
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