AI Article Synopsis
- * The structures of these compounds were determined using high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy, and various computational techniques.
- * Biochemical tests showed that certain ganodercins (Q, R, and W) enhance insulin signaling and glucose absorption, while others (ganodercins V and S) reduce collagen I expression, suggesting potential health benefits in terms of insulin resistance and kidney protection.
Article Abstract
Five undescribed benzopyran containing meroterpenoids, ganodercins Q－U, two undescribed benzofuran containing meroterpenoids, ganodercins V and W, and two known meroterpenoids were isolated from Ganoderma cochlear. Their structures were elucidated by using HRESIMS, NMR spectroscopy and computational methods. The results of biochemical studies using a palmitic acid (PA) induced insulin resistance (IR) model show that (-)-ganodercin Q, (+)-ganodercins R and W activate phospho-AKT (p-AKT) at 20 μM and improve glucose uptake in a concentration dependent manner. The results of renoprotection studies show that (+)-ganodercin S, cochlearol F, (+)- and (-)-ganodercins V reduce the expression of collagen I.
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| http://dx.doi.org/10.1016/j.phytochem.2022.113184 | DOI Listing |
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Article Synopsis
- * The structures of these compounds were determined using high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy, and various computational techniques.
- * Biochemical tests showed that certain ganodercins (Q, R, and W) enhance insulin signaling and glucose absorption, while others (ganodercins V and S) reduce collagen I expression, suggesting potential health benefits in terms of insulin resistance and kidney protection.
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