AI Article Synopsis
- The study aimed to examine how the number of penetrating keratoplasty (PK) procedures affects postoperative panel reactive antibody (PRA) levels and the number of unacceptable antigens in patients.
- A cross-sectional study was conducted, excluding patients with solid organ transplants, pregnancy, or blood transfusions, and focused on comparing patients with single vs. multiple PKs.
- Results showed that those with multiple PKs had higher PRA levels and a greater number of unacceptable antigens, indicating a correlation between the number of PKs and PRA levels that warrants further investigation.
Article Abstract
Purpose: To evaluate the relationship between penetrating keratoplasty (PK) and postoperative PRA level and number of unacceptable antigens.
Methods: A cross-sectionalstudy was performed on patients with history of PK. Patients with prior solid organ transplantation, pregnancy, or blood transfusion were excluded. These findings were combined with a retrospective review. Patients were grouped by single or multiple PKs. The primary outcome was postoperative PRA level.
Results: Incidence of postoperative PRA elevation and mean peak PRA was higher in the multiple PK group (p = .08 and p = .010, respectively). Mean number of unacceptable antigens was elevated in the multiple PK group (p = .024). There was a moderately positive correlation between number of PK grafts and PRA level (r = 0.629, p = .0002).
Conclusions: PRA level may be influenced by PKs, with higher PRA associated with increased prior PKs. Further studies are necessary to determine the potential prognostic value.: PK: penetrating keratoplasty; PRA: panel reactive antibodies; OSST: ocular surface stem cell transplantation; LSCD: limbal stem cell deficiency.
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| http://dx.doi.org/10.1080/09273948.2022.2060263 | DOI Listing |
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