Infant-Type Hemispheric Glioma in a Chinese Girl: A Newly Defined Entity.

Infant-type hemispheric glioma is a newly defined entity in the updated 2021 WHO classification of tumors of the central nervous system. This lesion occurs in the cerebral hemispheres of newborns and infants and harbors molecular alterations in the NTRK family, or . A four-month-old female infant presented with a large space occupying lesion of the left cerebral hemisphere, whose histological manifestation was high-grade hemispheric infantile glioma. Tumor expressed panTRK, indicative of rearranged , which was validated by next generation sequencing (NGS) as fusion. There was homozygous deletion of , and there were and mutations. The additional genetic alterations in this case may expand the genotypic spectrum of this distinct cohort.