AI Article Synopsis
- Surgeons and trainees can significantly benefit from collaborating with basic scientists through research, as they can identify important clinical questions and provide necessary human materials.
- The review focuses on research regarding the intestines' nervous system and how findings from animals have been applied to human cases.
- Innovative techniques like immunohistochemistry and retrograde tracing have improved our understanding of the human enteric nervous system and led to new treatment trials for gastrointestinal issues.
Article Abstract
Background: There are considerable advantages and opportunities for surgeons and trainee surgeons in conducting a period of research allied with basic scientists. Such clinicians are well placed to define relevant clinical questions, provide human material (tissue, biopsy and blood) and translate the techniques derived in experimental animals to human subjects.
Methods: This small review explores research conducted on the nervous system of the intestines, with an emphasis on the translation of findings from animal to human.
Results: This work shows that new techniques of immunohistochemistry and retrograde tracing, developed in animal tissue, have greatly expanded our knowledge of the structure of the human enteric nervous system.
Conclusions: Such findings have sparked therapeutic trials for the treatment of gastrointestinal disorders in patients.
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| http://dx.doi.org/10.1111/ans.17688 | DOI Listing |
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