Objective: Interference control is used to overcome conflict among competing memory representations and may contribute to memory difficulties in ADHD. This meta-analytic review examined memory interference to evaluate susceptibility to proactive, retroactive, and memory control interference among those with ADHD.
Method: Twenty studies (1987-2019) examining verbal memory interference in ADHD met inclusion criteria (age: 8-36 years). Proactive and retroactive interference indices were extracted from list-learning tasks, and memory control indices were extracted from experimental paradigms (e.g., directed-forgetting).
Results: Children with ADHD were affected by proactive interference (=-0.53, 95% CI [-0.75, -0.31]), whereas no significant differences were found in adults (=0.13, 95% CI [-0.02, 0.28]). Adults and children with ADHD exhibited retroactive interference (=0.17, 95% CI [0.05, 0.29]) and performed worse on memory control tasks (=0.35, 95% CI [0.08, 0.62]) relative to controls.
Conclusion: Differences in verbal memory interference control in ADHD were observed but effects were different depending upon interference type and participant age.
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http://dx.doi.org/10.1177/10870547221085515 | DOI Listing |
Biosci Trends
January 2025
Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cognitive impairment refers to the impairment of higher brain functions such as perception, thinking or memory that affects the individual's ability to perform daily or social activities. Studies have found that changes in neuronal activity during tasks in patients with cognitive impairment are closely related to changes in cerebral cortical hemodynamics. Functional near-infrared spectroscopy is an indirect method to measure neural activity based on changes in blood oxygen concentration in the cerebral cortex.
View Article and Find Full Text PDFNat Commun
January 2025
The Picower Institute for Learning and Memory, MIT, Cambridge, MA, USA.
Many essential proteins require pyridoxal 5'-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and neurotransmitter metabolism. A third of all mammalian pyridoxal 5'-phosphate-dependent enzymes are localized in the mitochondria; however, the molecular machinery involved in the regulation of mitochondrial pyridoxal 5'-phosphate levels in mammals remains unknown.
View Article and Find Full Text PDFJ Microbiol Biotechnol
November 2024
Department of Biotechnology and Department of Integrative Food, Bioscience and Biotechnology (BK21 FOUR), Chonnam National University, Gwangju 61186, Republic of Korea.
This study investigates the modulatory effects of nicergoline, a major bioactive compound derived from ergot fungus, on the 5-hydroxytryptamine 3A (5-HT3A) receptor. Utilizing a two-electrode voltage-clamp technique, we evaluated the impact of nicergoline on the 5-HT-induced inward current (I) in 5-HT3A receptors. Our findings reveal that nicergoline inhibits I in a reversible and concentration-dependent manner.
View Article and Find Full Text PDFJ Cannabis Res
January 2025
Department of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Background: The effect of oral Cannabidiol (CBD) on interference during learning and memory (L&M) in healthy human volunteers has not been studied.
Method: A two-arm crossover, randomized, double-blind, placebo-controlled trial was conducted at Colorado State University Pueblo (CSU Pueblo) to evaluate the effects of 246 mg oral CBD on L&M in healthy adults. Among 57 healthy volunteers enrolled, 35 were included in the analyses.
Neurosurg Rev
January 2025
Department of Neurosurgery, Hospital Universitario Fundación Jiménez Díaz, Av. De los Reyes Católicos, 2, Madrid, 28040, Spain.
Matched-controlled long-term disease evaluation and neuropsychological outcomes derived from deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson´s disease (PD) are lacking, with inconsistent results regarding the cognitive impact of this procedure. Here we study the long-term effects associated to DBS comparing outcomes with a matched control group. A prospective observational study of 40 patients with PD with bilateral STN-DBS, with a mean follow-up of 9 (6-12) years was conducted.
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