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Post-acute sequelae of COVID-19 (PASC): a meta-narrative review of pathophysiology, prevalence, and management. | LitMetric

Post-acute sequelae of COVID-19 (PASC): a meta-narrative review of pathophysiology, prevalence, and management.

SN Compr Clin Med

Division of General Internal Medicine, Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224-1865 USA.

Published: April 2022

AI Article Synopsis

  • COVID-19 is caused by the SARS-CoV-2 virus and has impacted over 220 countries, with rising infection rates and lingering symptoms in recovering patients.
  • Understanding how demographics and pre-existing health conditions affect these symptoms is key for clinical management of post-acute sequelae of COVID-19 (PASC).
  • This review focuses on recent research about PASC, detailing the condition, comparing it to acute COVID-19, identifying at-risk patient groups, and offering management recommendations for common complications.

Article Abstract

Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 220 countries and territories have been affected by this virus, and the infection rate has continued to rise. As patients recover from the virus, many are experiencing lingering symptoms. Understanding the impact of demographics and comorbidities on symptom prevalence, manifestations, and severity is not only relevant during acute infection, it is critical to the clinical management of patients with post-acute sequelae of COVID-19, also known as PASC. Herein, we provide a comprehensive review on the most recent research related to PASC. Specifically, we focus on the description of the disorder itself, compared to acute COVID-19, and which types of patients are most affected by long-term sequelae. Further, we share recommendations for management of the most common complications of PASC.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977184PMC
http://dx.doi.org/10.1007/s42399-022-01167-4DOI Listing

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