Behçet's disease is an inflammatory vasculitis with the unique feature of pulmonary artery aneurysms. We describe a patient with Behçet's disease and pulmonary artery aneurysms who presented with massive hemoptysis treated by coil embolization. Although there was immediate resolution of hemoptysis and improvement in hemodynamic status, 2 months later the patient reported a refractory cough and feeling of foreign body in her throat. Imaging demonstrated partial coil migration into the bronchus and trachea. Although endovascular intervention is the first-line treatment for massive hemoptysis, in patients with Behçet's disease, active inflammation and chronic steroid use may increase the risk of coil erosion and migration.
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http://dx.doi.org/10.1016/j.jvscit.2022.02.006 | DOI Listing |
Elife
December 2024
Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Because of high mutation rates, viruses constantly adapt to new environments. When propagated in cell lines, certain viruses acquire positively charged amino acids on their surface proteins, enabling them to utilize negatively charged heparan sulfate (HS) as an attachment receptor. In this study, we used enterovirus A71 (EV-A71) as model and demonstrated that unlike the parental MP4 variant, the cell-adapted strong HS-binder MP4-97R/167G does not require acidification for uncoating and releases its genome in the neutral or weakly acidic environment of early endosomes.
View Article and Find Full Text PDFChembiochem
December 2024
China Three Gorges University, College of Biological and Pharmaceutical Sciences, No. 8, Daxue Road, 443002, Yichang, CHINA.
Methylation modification is a critical regulatory mechanism in epigenetics, playing a significant role in various biological processes. N6-methyladenosine (m6A) is the most prevalent modification found in RNA. This modification is dynamic and reversible, regulated by methyltransferases and demethylases.
View Article and Find Full Text PDFPlant Signal Behav
December 2025
School of Medical Technology, Chongqing Three Gorges Medical College, Chongqing, China.
The most damaging disease affecting citrus globally is Huanglongbing (HLB), primarily attributed to the infection by ' asiaticus' (Las). Based on comparative transcriptome data, two cellulose synthase (CESA) genes responsive to Las infection induction were screened, and one gene cloned with higher differential expression level was selected and named . we verified the interaction between CsCESA1 and citrus exopolysaccharide 2 (CsEPS2) proteins.
View Article and Find Full Text PDFJMIR Rehabil Assist Technol
December 2024
College of Arts, Business, Law, Education and IT, Victoria University, Footscray Park, Australia.
Background: Evidence suggests that individuals with motor neuron disease (MND), a terminal illness, find enjoyment and social connection through video games. However, MND-related barriers can make gaming challenging, exacerbating feelings of boredom, stress, isolation, and loss of control over daily life.
Objective: We scoped the evidence to describe relevant research and practice regarding what may help reduce difficulties for people with MND when playing video games.
Chem Biodivers
December 2024
Noakhali Science and Technology University, Microbiology, Sonapur, Noakhali, BANGLADESH.
Cryptococcus neoformans, the most opportunistic fungal pathogen, causes cryptococcal meningitis. Based on molecular docking and ADME/toxicity analysis, the top two lead compounds selected from a screening of 5,807 phytochemical compounds from 29 medicinal plants were CID_8299 and CID_71346280, with docking scores of -5.786 and -6.
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