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Semiquantitative 2-[F]FDG PET/CT-based parameters role in lymphoma.
Front Med (Lausanne)
December 2024
Dipartimento di Radiodiagnostica e Radioterapia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
2-deoxy-2-[F]-fluoro-D-glucose (2-[F]FDG) positron emission tomography/computed tomography (PET/CT) plays a crucial role in the management of lymphoma in different settings, such as staging disease, assessing response to therapy, predicting prognosis, and planning RT. Beside visual analysis, several semiquantitative parameters were introduced to study lymphoma with promising results. These parameters can represent different disease characteristics, like body composition (such as sarcopenic index), dissemination of disease (Dmax), tumor burden (including metabolic tumor volume) and texture features.
View Article and Find Full Text PDF[F]FDG PET/CT Beyond Staging: Prognostic Significance of Sarcopenia and Adipose Tissue Metabolism in Esophageal Carcinoma.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
December 2024
Department of Radiology, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
Aim: This study aimed to investigate the relationship between PET and CT parameters and sarcopenia, adipose tissue, and tumor metabolism in esophageal carcinoma(EC) and its impact on survival in EC.
Method: Our study included 122 EC patients who underwent PET/CT for staging. Muscle and adipose tissue characteristics were evaluated, including lumbar(L3) and cervical(C3) muscle areas, psoas major(PM) and sternocleidomastoid muscle(SCM) parameters, and PET parameters for visceral and subcutaneous adipose tissue(SAT).
A systematic review of the accuracy of prognostic tests and scoring systems for use in the Global Vascular Guidelines' PLAN concept for the treatment of chronic limb threatening ischaemia.
J Vasc Surg
December 2024
Department of Vascular Surgery, st. Antonius Hospital Nieuwegein, the Netherlands.
Introduction: The 2019 Global Vascular Guidelines recommend risk assessment for evidence based revascularization based on the acronym PLAN; Patient risk, Limb severity and ANatomical complexity of disease. This meta-analysis compares a multitude of prognostic tests within these categories.
Methods: A systematic review and meta-analysis of tests that estimated 1 year major event (amputation free survival and major adverse limb events) probability.
Comparison Between Single- and Multi-slice Computed Tomography Body Composition Analysis in Patients With Oesophagogastric Cancer.
J Cachexia Sarcopenia Muscle
February 2025
Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
Article Synopsis
- This study investigates the effectiveness of single-slice versus multi-slice computed tomography (CT) methods in analyzing body composition in patients with oesophagogastric cancer, focusing on their correlation and impact on survival rates.
- Researchers examined CT scans of 504 patients, comparing measurements of skeletal muscle, subcutaneous, visceral, and intermuscular adipose tissue, finding high correlation and narrow limits of agreement between the two methods.
- Results indicate that both measurement techniques offer similar insights into body composition, suggesting that the clinical use of multi-slice analyses may be beneficial but requires further exploration for optimal application.
CT-Based Body Composition and Frailty as Predictors of Survival Among Older Adults With Gastrointestinal Malignancies.
J Cachexia Sarcopenia Muscle
December 2024
Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Background: Older adults with cancer are at an increased risk of treatment related toxicities and early death. Routinely collected clinico-demographic characteristics inadequately explain this increased risk limiting accurate prognostication. Prior studies have suggested that altered body composition and frailty are independently associated with worse survival among older adults with cancer; however, their combined influence remains unclear.
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