AI Article Synopsis
- * GOS improved the integrity of the intestinal villi and increased expression of tight junction proteins, while also boosting mucin and secretory IgA production to help alleviate inflammation.
- * Additionally, GOS positively influenced the balance of beneficial gut bacteria, enhancing the overall adaptability of the intestinal microbiome in response to stress from LPS exposure.
Article Abstract
Present study was conducted to comprehensively investigate the protective effects of galactooligosaccharides (GOS, 100%) against LPS-induced intestinal barrier damages, and the regulatory effect for intestinal microbes. Results showed that GOS intervention restored villi (jejunum and ileum) integrity, which were atrophic and broken in LPS-challenged mice. Electron microscopy, western blotting and immunofluorescence analysis exhibited that mice administrated with GOS showed higher expression of tight junction, which was confirmed in IPEC-J2 cells model. Meanwhile, the GOS increased the secretion of mucin and SIgA, as well as it alleviated inflammatory response caused by LPS in NF-κB dependent way. Administration of GOS could also increase the relative abundances of several specific friendly bacteria, and enhance the adaptability of intestinal microbiota. Collectively, these results indicated the potential of GOS for protecting intestine from injuries caused by stress as LPS challenge.
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| http://dx.doi.org/10.1016/j.foodres.2022.111003 | DOI Listing |
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