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Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma.
Free Radic Biol Med
January 2025
Mātai Hāora, Centre for Redox Biology and Medicine, University of Otago Christchurch, Christchurch, New Zealand. Electronic address:
Cutaneous melanoma is a highly invasive, heterogeneous and treatment resistant cancer. It's ability to dynamically shift between transcriptional states or phenotypes results in an adaptive cell plasticity that may drive cancer cell invasion or the development of therapy resistance. The expression of peroxidasin (PXDN), an extracellular matrix peroxidase, has been proposed to be associated with the invasive metastatic melanoma phenotype.
View Article and Find Full Text PDFThe importance of multiple Z- plasty- assisted physical therapy in the treatment of Dupuytren's contracture.
J Orthop Surg Res
January 2025
Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: The palmar aponeurosis is extremely adherent to the skin above it. Many of the pre-tendinous coarse fibers enter the dermis at an angle, not just in the palmar creases but also throughout the palm. It's difficult to distinguish whether Dupuytren's illness starts in the skin's dermis or the palmar aponeurosis since the skin adheres so closely to the palmar fascia.
View Article and Find Full Text PDFThe impact of different occlusal guard materials on Candida albicans proliferation in the oral cavity.
Cell Mol Biol (Noisy-le-grand)
November 2024
Water Resources Engineering Department, College of Engineering, University of Duhok, Kurdistan Region- Iraq.
Candida albicans is an opportunistic fungal pathogen. It's a dimorphic fungus with hyphal form that can penetrate and proliferate the oral mucosa. Occlusal guard materials come into direct contact with the oral mucosa and saliva when worn for extended periods, the occlusal guard acts as a reservoir for C.
View Article and Find Full Text PDF[Research progress of Schöttle's method for femoral tunnel localization in medial patellofemoral ligament reconstruction].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
December 2024
Department of Orthopaedics, the Second Hospital of Lanzhou University, Lanzhou Gansu, 730030, P. R. China.
Objective: To review the research progress of Schöttle's method in medial patellofemoral ligament reconstruction (MPFLR), and provide the latest knowledge and suggestions for surgical treatment.
Methods: The studies on Schöttle's method at home and abroad in recent years were extensively collected, then summarized the problems affecting the accuracy of Schöttle's method and the new ideas to improve the accuracy of localization.
Results: It's vital to accurately locate the femoral tunnel during MPFLR.
Microplastics/nanoplastics and neurological health: An overview of neurological defects and mechanisms.
Toxicology
December 2024
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University,Nantong, Jiangsu Province 226001, China. Electronic address:
The widespread use of plastic products worldwide has brought about serious environmental issues. In natural environments, it's difficult for plastic products to degrade completely, and so they exist in the form of micro/nanoplastics (M/NPs), which have become a new type of pollutant. Prolonged exposure to M/NPs can lead to a series of health problems in humans, particularly toxicity to the nervous system, with consequences including neurodevelopmental abnormalities, neuronal death, neurological inflammation, and neurodegenerative diseases.
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