We show how to deal with uncertainties on the Standard Model predictions in an agnostic new physics search strategy that exploits artificial neural networks. Our approach builds directly on the specific Maximum Likelihood ratio treatment of uncertainties as nuisance parameters for hypothesis testing that is routinely employed in high-energy physics. After presenting the conceptual foundations of our method, we first illustrate all aspects of its implementation and extensively study its performances on a toy one-dimensional problem. We then show how to implement it in a multivariate setup by studying the impact of two typical sources of experimental uncertainties in two-body final states at the LHC.
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http://dx.doi.org/10.1140/epjc/s10052-022-10226-y | DOI Listing |
Med Phys
January 2025
Department of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Background: Modern reconstruction algorithms for computed tomography (CT) can exhibit nonlinear properties, including non-stationarity of noise and contrast dependence of both noise and spatial resolution. Model observers have been recommended as a tool for the task-based assessment of image quality (Samei E et al., Med Phys.
View Article and Find Full Text PDFNature
January 2025
Machine Learning Lab, University of Freiburg, Freiburg, Germany.
Tabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science. The fundamental prediction task of filling in missing values of a label column based on the rest of the columns is essential for various applications as diverse as biomedical risk models, drug discovery and materials science. Although deep learning has revolutionized learning from raw data and led to numerous high-profile success stories, gradient-boosted decision trees have dominated tabular data for the past 20 years.
View Article and Find Full Text PDFNature
January 2025
Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA, USA.
Microscopy and crystallography are two essential experimental methodologies for advancing modern science. They complement one another, with microscopy typically relying on lenses to image the local structures of samples, and crystallography using diffraction to determine the global atomic structure of crystals. Over the past two decades, computational microscopy, encompassing coherent diffractive imaging (CDI) and ptychography, has advanced rapidly, unifying microscopy and crystallography to overcome their limitations.
View Article and Find Full Text PDFEur Radiol
January 2025
Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Background: Chronic liver disease (CLD) is a substantial cause of morbidity and mortality worldwide. Liver stiffness, as measured by MR elastography (MRE), is well-accepted as a surrogate marker of liver fibrosis.
Purpose: To develop and validate deep learning (DL) models for predicting MRE-derived liver stiffness using routine clinical non-contrast abdominal T1-weighted (T1w) and T2-weighted (T2w) data from multiple institutions/system manufacturers in pediatric and adult patients.
Anaesthesia
January 2025
Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Introduction: Understanding 1-year mortality following major surgery offers valuable insights into patient outcomes and the quality of peri-operative care. Few models exist that predict 1-year mortality accurately. This study aimed to develop a predictive model for 1-year mortality in patients undergoing complex non-cardiac surgery using a novel machine-learning technique called multi-objective symbolic regression.
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